Agnus Castus and PMS: Don’t buy it from Boots or Holland & Barrett if you actually want it to work

agnus castus flowerDear Juliet,

I ended up on your blog  while looking for information about agnus castus and PMS.

A few months ago a counsellor asked me whether the episodes of anger or low self worth were happening at any particular time. For the first time in more than 10 years of counselling, therapy, CBT etc I realised that there might be a connection between me feeling like not me and PMS. I started looking into it and a set of completely new ideas opened in front of me. First, is the idea that the emotional pain I carry with me could actually be triggered from something different than my mind. Second is the idea that there are remedies.

It is so great to receive an email like that, however, the writer of the email is finding it difficult to get the correct dosage of Agnus Castus and more importantly ascertain what the correct dosage is, as each supplier seems to calculate the active ingredients completely differently.

For example:

Nature’s Best sell 100mg tablets, equivalent to 100omg of fruit, ratio 10:1 (this old stock*).

Prime Health, advertise (although you can’t actually purchase it) 20mg standardised extract tablets, equivalent to 24omg dried fruit, ration 12:1. This is the dosage described in the clinical data, and the only one I understand.

Herbs sell Agnus Castus Tincture 1ml equivalent to 500mg, ratio 1:2 (again this is advertised as old stock.*)  This is the response I received to information on dosage. “Our dose equivalence is 1ml (ie 10 drops) to 500mg of dried herb.  So to get close to your current tablet equivalence you would take 0.4ml or 0.5ml (4 or 5 drops) three times a day.” (remember this is old stock, so you would have to take 5 times that, once new stock carries the THR logo.)

*The reason these companies are pointing out they are selling old stock is because the new regulations of herbal medicines has restricted the amount of active ingredient per tablet/ ml. What that means is the recommended dosage is no longer based on data from clinical trials, but rather is based on the restrictions of selling herbal remedies under the Traditional Herbal Registration license (THR).

In short, up until 2011 herbal medicines were unlicensed (meaning dosage was not restricted). Since 2011 all suppliers of herbal remedies must apply for a license. In the case of Agnus Castus there are two sorts of licenses. The Traditional Herbal Registration (THR), which restricts dosage to 4mg per tablet, or the Marketing Authorization (MA), which would allow dosage of 20mg (based on Well Established Use). The information on dosage allowed under each type of license can be found in the EMA Community Monograph, which is the document to which member states should refer to when deciding on whether to an issue a license or not.

Unfortunately, most high street and online stores have applied and been granted a Traditional Herbal Registration (THR), which means they can’t sell any Agnus Castus with a dosage higher than 4mg.

If it has this logo, then the dosage can be no more than 4mg per tablet.
If it has this logo, then the dosage can be no more than 4mg per tablet.

So where you see the THR symbol on herbal remedies, it is a guarantee the dosage will be too low to have an effect. This means products from Boots, Kira and Holland & Barrett are not worth buying (unless you’re can afford and are prepared to take 5 tablets each day.) They are selling 4mg tablets at the same price they used to sell 2omg tablets.

Why has the EMA interfered? I hear you ask.

It seems there is a grave fear in Europe that herbal medicines are dangerous and in particular they interact with prescribed drugs leading to undesirable effects. To protect the (silly) public all herbs must have a license in order to be sold. THR license is based on traditional use for thirty years, and doesn’t require rigorous clinical trials to be granted (even though there are rigorous clinical trials accepted by the EMA for Agnus Castus).  Because of the lower requirements for THR, that means the dosage is set at a level where it is unlikely to have any effect (adverse of therapeutic). Which makes you wonder why Boots would bother selling the products at all (I have emailed Boots this very question and will post their response). They are in fact cheating their customers, by implying the drug will work at the lower dosage, despite overwhelming clinical evidence to the contrary.

So where can you get the correct dosage of Agnus Castus from?

1) Not from any supplier who has a THR license. If it’s got the THR logo, then it is going to be too low to be effective. You will need 5 times the dosage suggested. Products from Boots, Holland & Barrett, Healthspan, Kira all carry the THR logo.

2) Some companies are still selling old stock, this is likely to be at higher dosage. If it doesn’t have the THR logo it is likely to be old stock. Nature’s Best, mentioned above, wrote to me about their dosage, and the problems they are experiencing in restocking:

“The Natures Best Vitex Agnus Castus currently provides 100mg of Vitex Agnus Castus fruit extract at a one a day dose.  This is a 10:1 extract which means the starting material is 1000mg (dried fruit).  Vitex contains the flavonoid casticin and we ensure that that our extract contains not less than 0.4% casticin per tablet which is an excellent marker of potency. At the time of formulating this herb we did review all of the data referring to tincture, traditional use and extracts that were available.  This was launched 14 years ago and we have received excellent feed-back from
customer who have used it.

In April 2011 the status of this herb changed from food supplement to medicine.  We have applied for a medicinal licence but we are struggling to get the potency to match our current product.  Nothing has been finalised yet and once we sell through our stock of food supplements, we will have to wait for our licensed product to become available.   We are close (weeks away) from running out and although this may appear like a hard sell, I am really only telling you so you have the choice.”

3) If the product has a PL code (product license required for all medicines), which means the supplier has obtained Marketing Authorisation. Although I have not as yet found any supplier that has got an MA, I do have an email from one, who is attempting to get this (and will give you their details as soon as I can). I have also emailed the MRHA (UK regulatory body for medicines) to ask them if they have a list of suppliers who have applied for the Market Authorisation. I await their reply.

4) Finding a supplier outside of the EU (possibly US or Canada).

I wish the news was better, but the EU regulations have, in effect, decimated the herbal medicines industry, rendering the herbs ineffective, by restricting dosage to levels too low to be effective (this hasn’t just affected Agnus Castus). For more on the herbal industry’s take on the regulations, click here.

Something is very wrong here. You have to wonder who really benefits from these regulations (the public or the drug companies), because as one herbal company, who emailed me this morning said:

“The pharmacists at the MHRA will have their way with regard to recommended doses, their is nothing that can be done to prevent that. As you cannot patent a herb, it is highly unlikely a company would go to the expense of trials to justify market authorisation. So it is most likely once current stocks are are sold through and the MHRA has attacked the sale of agnus castus food supplements that agnus castus will only be sold at very low doses.”

Link to fees for Market Authorisation and Traditional Herbal Registration.

The main medical treatments offered for PMT are anti-depressants and hormonal treatments (with the well documented side effects), despite the overwhelming evidence that Agnus Castus works (with minimal side effects). Doctors cannot prescribe Agnus Castus in the UK because it is not listed in the BNF (the British National Formulary).

All I want is somewhere I can buy the correct dose of Agnus Castus and continue to be free of the debilitating PMT I suffered for years under the ‘care’ of a gynaecologist. Is that too much to ask?

If anyone else finds old stock of Agnus Castus, post a link here. Or if you find a supplier that has a PL code, please let us know.

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408 thoughts on “Agnus Castus and PMS: Don’t buy it from Boots or Holland & Barrett if you actually want it to work”

  1. Just to share with everyone what I’ve learned from my experience with Agnus Castus and seeking advice about it – Agnus Castus will only work for you if your PMS symptoms are the result of low progesterone. if they’re the result of low oestrogen, Agnus Castus could make them worse, as it did for me. Be aware, perhaps have your hormone levels tested, and don’t expect your GP or the average health food shop to understand this distinction!

    1. Hi Rachael, what I shame you did not get the relief from taking agnus castus. I do hope you find something that does work for you. I am not sure researchers really understand how agnus castus works nor whether it is only effective when progesterone levels are low. I wouldn’t suggest the majority of women need to have hormone levels tested, rather trying different herbs to find one that works – if it works it doesn’t really matter which hormone is low. Some women have responded better to red clover and black cohosh – Natural Health Practice combines black cohosh with agnus castus for example. Let us know how you get on.

    1. not sure about these products. However, I do know that all these brands have THR (traditional herbal registration) and are restricted therefore to no more than 4mg (30-52mg whole herb) per tablet/capsule/drops.

      Holland & Barrett
      GNC Live Well
      Lifecycle
      Nature’s Garden
      Nature’s Bounty
      A.Vogel
      Natures Aid

      I suggest you contact the companies to ask them how the dosage compares to the 20mg standardised extract quoted in trials.

      1. I found a site where you can buy dried agnus casus berries. What if you take 1 or 2 of thema day?

      2. Hi Rachael,

        Where can I find this pills? I got holland and Barret but not convince the dosage is enough.

        Thank you

        Agueda

  2. Thank you very much for your post. Wasn’t aware at all about the different dosage regulations! I found out that I was buying the right AC dosage pack *sigh of relief* However, I’m still in the dark as for how many pills a day to take and how – before or after food, and for how long. I would always take 2/day morning-evening and first it worked fine to bring my irregular cycle and side effects (maddening) such as water retention and huge appetite starting 2 weeks before the period to make me gain a lot of weight every time. But after taking AC for about a year now I started to notice that my last 4-5 periods were spread all over again becoming unpredictable, and these last 2 months my bad PMS symptoms returned 😦

    So, I started investigate if I was taking it correctly or what could cause the effect disappear.

    Any dosage advice? Thank you!

    1. Hi Julia, the best thing is to email Linden’s to find out how their dosage compares to the standardised extract (20mg) cited in research. It maybe their dosage is not as clear cut as you believe. Do let me know any news.

    1. I haven’t tried these – but if there really is 100omg it seems rather excessive as research suggests 200-600mg is more than enough. If I were to buy these, I would email the company to explain the dosage in relation the standardised extract (20mg) which is cited in research.

  3. I’ve just bought A.Vogel oral drops. (Wish I had read this first 😩) Very confused; it says ”33 drops contains 895mg of tincture from Agnus castus fruits” and recommends 15-20 drops twice a day. I told the guy in the, very reputable, independent health food shop that I wanted 200mg capsule or equivalent. But this product has THR logo on. He said that 5 drops would be about 400mg (i.e. Pro-rata) is this right? Planning on starting with 15 drops twice a day and see how I get on.

  4. Hi Juliet, I just wanted to thank you for this blog. Since finding it about a year ago, I’ve been using the organic tincture you listed above (following the dose on the label about 2.5ml or 25 drops a day) http://www.organic-herbal-remedies.co.uk/vitex-agnus-castus-tincture-100ml-1-p.asp and it has really helped with almost all my PMS symptoms. I’ve also been on an organic paleo diet and that has just about eliminated any bloating (which seems to be directly linked to carbohydrates).

    The pharmaceutical products (various versions of the pill) I tried before seemed to make things worse and the THR Agnus castus was a waste of time. Finding your blog has literally changed my life!

  5. Hi I am suffering from hormonal acne, the nasty hard painful lumps on my chin. I’ve done some research, and Agnus Castus seems to be recommended in most cases. However, I cannot find any information on this condition, and the effects of Agnus Castus on women like me, who have had a complete Hysterectomy. Can anyone throw some light on this please?

    1. Hi Hazel, I don’t know the answer I am afraid. Whether the body still produces some estrogen after a complete hysterectomy where the ovaries are removed. I guess you have nothing to lose by trying AC for a couple of months if you think the acne is hormone related. Equally, I don’t know how long ago you had surgery and how long the body takes to adjust. Best wishes.

    1. Hi Stace, looking at the Herbal Monograph ‘Traditional Use’ has been variously described as:

      Posology
      Adults

      Daily dose:
      a) two times daily 400 mg powdered herbal
      substance
      b) once daily 40 drops
      c) once daily 30-40 drops corresponding to
      approximately 33 mg herbal substance
      d) once daily 4 mg dry extract corresponding
      to 28-52 mg herbal substance
      e) once daily 2-3 mg dry extract
      corresponding to 30-48 mg herbal
      substance

      This suggests the company are using a) to explain their dosage. However they explain it, if it has the THR logo then each tablet can only be equivalent to 4mg (standardised extract).

  6. Hi Juliet and others on this post…..

    I really appreciate all the information here and stumbled across it while researching Anna’s wild yam cream, which contains angus castus. However the yam cream seems to be very expensive (it also contains black cohosh and other ingredients). Having now read more about angus castus I would first like to try this for my pmt issues and see if it works as its a more affordable option for me.

    Unfortunately of the 3 brands you mention only the tincture is available for delivery to Dubai where I live. Does anyone know of a high quality and correct strength product I can buy in Dubai or have delivered? Some of the brands I know are available are:

    – NaturesWay 400mg (I read the good reviews are mostly fake which is worrying)
    – premeze – 400mg (I need to understand this compared to STANDARDISED dose as suggested in this post)
    – natures answer – 40mg

    I appreciate any feedback on these brands or alternatives for Dubai.

    Many thanks,
    H

    1. Hi Hannah, I am pretty sure the Natures answer is 4mg standardised or 40mg whole herb, so you would need 3 to 4 of these to get correct dosage. Nature’s way and Premeze I really do not understand the dosage. This is a list of companies that have THR and therefore dosage will only be maximum 4mg standardised: Holland & Barrett.
      GNC Live Well
      Lifecycle
      Nature’s Garden
      Nature’s Bounty
      A.Vogel
      Natures Aid

      1. Thanks for getting back to me so quickly Juliet 🙂 and for the list. It’s a bit naughty that natures way is not advertising the THR logo on packaging so it is unclear for consumers which dosage it is apart from ‘400g’. I’m contacting some other companies that distribute to Dubsi and crossing my fingers! Best,
        H

      2. Hi again,

        So I’ve just heard back from natural health practice and unfortunately they can no longer sell Agnus castus! The email is below along with a suggested alternative.

        I found another brand available from US called puritans pride and they report 400mg on the front of the bottle and 800mg per 2 capsule serving….this seems high? I’m waiting to hear back from them. No THR logo though.

        Have you heard of puritans?

        This is the email from natural health practice:

        Unfortunately due to a ruling just advised by the MHRA* , our industry regulations advisor, we are no longer able to sell our current formulation of Agnus Castus as Agnus Castus are deemed to be medicinal product.

        We undertook two years of determined campaigning to maintain the right to provide you with our unique Agnus Castus formulation but it now cannot be sold as a food supplement. You will see other Agnus Castus supplements remain available for sale but they have much lower, less effective, herb extract levels allowing them to be sold as a Traditional Herbal Remedy (THR) and usually have other excipients added like fillers, binders, lubricants, anti-caking agents etc. which none of the NHP supplements contain.
        However, as disappointed as we all are about this and as you would expect from NHP, we had a contingency plan just in case we lost.
        We consulted with Dr Marilyn Glenville PhD and in association with NHP she agreed to formulate a new premium quality food supplement to replace the Agnus Castus for you. (The email went on…)

        Best,
        H

      3. That is terrible news about the Natural Health Practice. I do hope they can come up with a new supplement to replace it. Thanks for letting us know and please do report back about Puritan’s Pride, but not sure we can access it in UK.

  7. I know, it was disappointing g news from natural health practice, to follow on from the email I pasted above, below is more information about their new product. They are very optimistic about it and offering satisfaction guaranteed which is good:

    ‘Dr Glenville formulated ‘PM Support’ which she is confident you will be just as pleased with.

    PM Support from the Natural Health Practice is a very special formulation designed to support you through the month. It contains a combination of carefully chosen nutrients including all the B vitamins and magnesium (for nervous system), chromium (for blood sugar balance), Siberian ginseng (for stress), chamomile (for nervous system) and dandelion (for liver support). PM Support includes vitamin B6 which can contribute to the regulation of hormonal activity and reduction of tiredness and fatigue. Take PM Support and take back control of your life and cycle.’

    Look forward to hearing how people get on with this product and I will keep you posted on Puritan pride if I go with that brand.

    Best,
    H

    1. but it contains no agnus castus, which is the herb we know works because of research trial results. A real shame, although the company did try by not standardising herb and selling as a food product. In the meantime women continue to prescribed prozac rather than this safe and effective herb. So frustrating – but thanks for sharing the email.

  8. Hi. I have some experience with herbalism and have also used Agnus Castus with amazing effect during Menopause when nothing else was available. My recommendation would be to only use a tincture – no pills or whatever. 40 drops in water first thing in the morning as soon as you get up, religiously every day. The tincture is alcohol based so tastes foul – if you put the drops in boiling water most of the alcohol evaporates off and you can then add cold water and drink it, but I gave up bothering with that because it was hard enough keeping up with taking it every morning – and I got used to the foul taste and just ate something afterwards to take the taste away. I am not good with remembering to take something every day but when you are that bad you remember! (Flooding). It is used as a convetional menopause remedy in Germany and is known as a safe herb – unlike a lot of other herbs that are sold for PMT and menopause which can have issues (eg Black Cohosh, Red Clover and so on) due to oestrogen levels. Agnus Castus does not contain oestrogen – it works on the pituitary gland and helps balance it – the pituitary gland sends signals to the hormone producing organs and tells them how much to produce. Effectively it balances the oestrogen and progesterone levels. Too much oestrogen and you get one set of symptoms, too much progesterone and you get others (whether for PMT or menopause) so having those balanced relieves symptoms either way. It’s supposed to take approx 2 months to start taking effect so taking it every day is necessary. But I found a massive help within 2 weeks. Hope this helps. I used a number of different manufacturers tinctures, depending on what I could get hold of but A Vogel make a good one.

    40 drops in water first thing in the morning (the dose should be on the tincture bottle).

  9. PS It doesn’t need to be a whole glass of water – a small amount of water is easiest because it can be swigged down in one, even though the taste is stronger.

  10. You’re welcome 🙂 Note: It shouldn’t be taken for more than a certain period of time (I forget but I think it’s 3 to 4 months). And then a break of a year before taking it again. But the theory is that once taken for 3 to 4 months and stopped, the symptoms don’t recur. That is what happened with me. I stopped it after 3 months and never needed to take it again – it cured the problem long term.

  11. Hi All
    this is all very interesting..i did not know about Agnus Castus liquid form and have just bought Lindens Agnus Castus tablets. I called Lindens first and have asked them about their product and they told me each tablet contains Agnus Castus extract equivalent to 1000mg whole dried berry, standardised to yield 0.6mg Aucubin (what does it mean?) and they said to take one each day for two weeks and if i feel not working to take two a day, any thoughts on this?
    I wanna take Agnus Castus because I have amenorrehea due to years of competitive sport and low BM. Last year my doctor found my oestrogen was low and at risk of osteoporosis as a result of it, so he put me on a pill but I do not want to take the pill as it raises blood pressure (and my diastolic reading is already slightly high, inherited from my father!) so I read so much about this, i feel this could help me get my natural periods back now that I have stopped competitive sport and I have a good BM.
    So, I hope this Lindens Agnus Castus is really what they claim it is and if any of you have anything to add please do so. Does Agnus Castus have side effects? I will investigate on getting a liquid Agnus Castus if I see it is successful…

  12. Hi everyone,

    I’ve just received some rather confusing information which goes against the recommended 20mg per day and i can’t understand why, here is the message i received about the Bluebonnet agnus castus, does anyone know why they are suggesting such a high dose?

    “The daily amount of vitex berry extract (chasteberry) supported by research for women’s health issues ranges from 175 to 500 mg, depending on the concentration of agnusides, which should be standardized around 0.5%. It is not just the amount of vitex berry extract in each capsule that is significant, but rather the amount of the active constituent, agnusides, that are present. Therefore, an individual would benefit more from a vitex berry extract like Bluebonnet’s that has a higher amount of agnusides per serving. For example, Bluebonnet’s Standardized Vitex Berry Extract (Chasteberry) Capsules offer 225 mg of vitex berry extract standardized for 0.5% agnusides, which provides 1.13 mg/serving as opposed to a 500 mg vitex berry extract standardized for 0.2% agnusides, which provides only 1 mg/serving. So, the amount of vitex berry extract in the capsule is not the most significant factor. The guaranteed amount of agnusides is what is paramount. ♦

    Are formulated using a standardized vitex berry extract that contains 0.5% (1.13 mg) agnusides, which is a potent flavonoid that supports women’s and menopausal health. This active constituent is characterized by a very specific and reproducible HPLC profile, which is defined as the “fingerprint” of the extract.
    • Provide a vitex berry material that is grown in Europe and is sustainably wildcrafted since only the berries are utilized.
    • Are the second most competitively priced vitex berry extracts in the natural food marketplace standardized to one of the highest agnusides (1.13 mg) potencies .
    • Are supported by science at the agnusides potency levels in this formula to address the following applications:
    • Support women’s health (i.e., premenstrual syndrome and menopause) by:
    • Acting on the pituitary gland and suppressing prolactin release ♦
    • Acting as a dopamine antagonist ♦
    • Are one of the few standardized vitex berry extracts on the market available in vegetable-derived capsules (Vcaps®) rather than the industry standard of using animal-derived gelatin softgels/capsules for superior absorption and optimal bioavailability, delivering a truly vegetarian/vegan formula from inside out.
    • Gluten-Free
    • Soy-Free
    • Kosher-Certified – is the ONLY vitex berry extract on the market that is kosher
    100% Vegetarian/Vegan

    Kind regards,

    Bluebonnet Nutrition”

    Thanks
    H

    1. It is a very thorough response, which I find reassuring. Agnuside is the chemical component of agnus castus according to Wiki. The capsules offer 225mg (which is around 2omg standardised extract), so the dosage sounds about right. I can’t see the Traditional Herbal Registration mark, which would limit active ingredient to 4mg (around 52mg whole herb). They may well be worth trying. Thanks for sharing info.

      1. Thanks for the response….it is a very thorough response. How do you work out from the 225mg on their label equals around 20mg standardized extract? That’s the bit I’m lost on….thanks, H

  13. Thank you for your article, I looked at the link in your where to get Agnus, I am looking at the prime health direct one and it says 20mg, I have read I need 500-1000 miligrams for PCOS to regulate periods. Am I right in thinking that that would be 5 tables a day to get the 1000? With the maths youve talked about above? Or am I misunderstanding?
    Many thanks

    Beanie

    1. 20mg is the standardised extract – so the dosage is approximately 200mg per tablet. Not sure on the research for PCOS in terms of dosage, but the recommended is between 20-40mg standardised (180-500mg herb).

  14. Just to clarify, Bluebonnet Nutrition is an American brand (so THRs do not apply). Standardised extracts take a more pharmaceutical approach to herbal remedies, favouring particular phyto-chemicals rather than relying on the wholistic benefits of the whole herb as it grows naturally.
    With regard to the maths… when a ratio such as 1:10 or 1:2 is given for a herbal extract that refers to the ratio between the liquid that the herb is extracted into and the weight of the herb. So a one to ten ratio indicates 1 kilo of herb has been extracted into 10 litres of alcohol (or sometimes oil). A ratio of 1:2 is much stronger as one kilo is extracted into only 2 litres of alcohol. Those calculations can be taken one step further, so for a 1:10 ratio, 1ml of extract is equivalent to 100mg of herb and for a 1:2 ratio one ml of extract is equivalent to 500mg of herb.

  15. Just to say I have also found benefits from Angus castus however I am using Lindens which is the strongest one (equivalent to 1000mg) and I did wonder if this dose is too high? I can however report the increased libido effects and great mood have been great so far!

    1. So good to hear you have noticed improvements.

      Looking at the dosage info:

      1 tablet provides 100mg 10:1 Vitex Agnus Castus extract, equivalent to 1000mg whole dried berry, standardised to yield 0.6mg Aucubin

      That does sound high – but I think the aucubins is the important part (although I do not understand them).

  16. Hi i ordered the Angus cactus, and been trying them about 4/5 week. I came on my period today and although I do get a lot of pmt symptoms, mood swings, depressed, tired etc I never suffer with any physical pains. Today I have felt awful stomach cramps which I never get. Headache and just feel completely exhausted. I normally come on my period and feel so much better. So I am wondering if this could be due to the Angus cactus and has anyone else has experienced this. Thanks

    1. Hi Sally, I can’t really help with this I am afraid, as I predominantly took AC for period pain. What improvements have you noticed? and did the pain settle quickly? It may well be related to the AC, but it would be worth taking it for one more period to see if this is a one off. Do come back and let us know how you got on and if anyone has experienced this and can give Sally some advice that would be great 🙂

  17. hi, i am totally devastated as lindens have stopped selling there agnus castus and they are now selling on ebay for so much money, so here i am looking for something else.I really am devastated as without these tablets my moods and way of thinking are terrible. so i have ordered from prime health but i am guessing in time they will stop also and agnus castus will be impossible to get in the correct dosage, is one of these tablets per day enough to take or should i take 2. i dont understand why something that works so well and helps so many people has been taken off the market. i rely on these to be a sane normal woman so badly.

    1. Hi Emma, I feel your pain. Prime Health Direct have a big stock as I spoke to the manager recently – but I too worry about what happens if they are forced to stop selling it. The other option is tincture or buying the herb loose, which some sites have started doing. Sorry I can’t bring more reassuring news.

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